Macromolecular reviews, Vol. I.

Neuroscience & Biohehavioral Reviews, Vol

KRISTAL, M. B. Placentophagia: A biohehavioral enigma (or De gustibus non disputandum est). NEUROSCI. BIOBEHAV. REV. 4(2) 141-150, 1980. -Although ingestion of the afterbirth during delivery is a reliable component of parturitional behavior of mothers in most mammalian species, we know almost nothing of the direct causes or consequences of the act. Traditional explanations of placentophagia, su...

Attachment and Loss. Vol. I

Interactive macromolecular sites. I. Basic theory.

A general theory of the evolution of interactive surfaces or sites on cell macromolecules is presented based on the assumption that all macromolecules present in cells are covered with reactive groups to which counter sites can theoretically be made. Initially such potentially reactive sites are considered to exist in pairs. Once one member of a pair is incorporated into a cell, its opposite nu...

Nitric oxide release: part I. Macromolecular scaffolds.

The roles of nitric oxide (NO) in physiology and pathophysiology merit the use of NO as a therapeutic for certain biomedical applications. Unfortunately, limited NO payloads, too rapid NO release, and the lack of targeted NO delivery have hindered the clinical utility of NO gas and low molecular weight NO donor compounds. A wide-variety of NO-releasing macromolecular scaffolds has thus been dev...

CNS Drug Reviews, Vol. 4, No. 4, Winter 1998

The discovery of zonisamide (ZNS) did not result from a search for new antiepileptic drug (AED). A continuous random screening for anticonvulsant activity had been in progress for many years at the research laboratories of Dainippon Pharmaceutical Co., Ltd. ZNS was discovered by serendipity in 1974 during routine testing of 1,2-benzisoxazole derivatives which were synthesized for the management...